Impact of androgen deprivation therapy on the thymus and the production of naïve T-cells
نویسندگان
چکیده
Purpose A clinical trial was conducted employing androgen deprivation therapy (ADT) +/vaccine in patients (pts) with rising prostate specific antigen (PSA) after definitive therapy but no disease visible on bone or computed tomography (CT) scan. The primary endpoint was to determine if a whole tumor cell vaccine could prolong PSA recovery, but a key secondary endpoint was to evaluate the impact of ADT on the thymus and production of naïve T-cells. Previous studies suggest that ADT regenerates the thymus (in mice) and increases naïve T-cell production in humans [1].
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